医学
内科学
危险系数
长春瑞滨
肿瘤科
乳腺癌
化疗
艾瑞布林
吉西他滨
转移性乳腺癌
癌症
外科
胃肠病学
置信区间
顺铂
作者
Aditya Bardia,Sara A. Hurvitz,Sara M. Tolaney,Delphine Loirat,Kevin Punie,Mafalda Oliveira,Adam Brufsky,Sagar Sardesai,Kevin Kalinsky,Amelia Zelnak,Robert Weaver,Tiffany A. Traina,Florence Dalenc,Philippe Aftimos,Filipa Lynce,Sami Diab,Javier Cortés,Joyce O’Shaughnessy,Véronique Dièras,Cristiano Ferrario
标识
DOI：10.1056/nejmoa2028485
摘要
Patients with metastatic triple-negative breast cancer have a poor prognosis. Sacituzumab govitecan is an antibody-drug conjugate composed of an antibody targeting the human trophoblast cell-surface antigen 2 (Trop-2), which is expressed in the majority of breast cancers, coupled to SN-38 (topoisomerase I inhibitor) through a proprietary hydrolyzable linker.
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