Reduction of the canonical function of a glycolytic enzyme enolase triggers immune responses that further affect metabolism and growth in Arabidopsis

生物 免疫系统 烯醇化酶 糖酵解 生物化学 基因表达调控 基因 细胞生物学 新陈代谢 遗传学 免疫学 免疫组织化学
作者
Leiyun Yang,Zhixue Wang,Aiqin Zhang,Ruchika Bhawal,Chunlong Li,Sheng Zhang,Lailiang Cheng,Jian Hua
出处
期刊:The Plant Cell [Oxford University Press]
卷期号:34 (5): 1745-1767 被引量:14
标识
DOI:10.1093/plcell/koab283
摘要

Abstract Primary metabolism provides energy for growth and development as well as secondary metabolites for diverse environmental responses. Here we describe an unexpected consequence of disruption of a glycolytic enzyme enolase named LOW EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 2 (LOS2) in causing constitutive defense responses or autoimmunity in Arabidopsis thaliana. The autoimmunity in the los2 mutant is accompanied by a higher expression of about one-quarter of intracellular immune receptor nucleotide-binding leucine-rich repeat (NLR) genes in the genome and is partially dependent on one of these NLR genes. The LOS2 gene was hypothesized to produce an alternatively translated protein c-Myc Binding Protein (MBP-1) that functions as a transcriptional repressor. Complementation tests show that LOS2 executes its function in growth and immunity regulation through the canonical enolase activity but not the production of MBP-1. In addition, the autoimmunity in the los2 mutants leads to a higher accumulation of sugars and organic acids and a depletion of glycolytic metabolites. These findings indicate that LOS2 does not exert its function in immune responses through an alternatively translated protein MBP-1. Rather, they show that a perturbation of glycolysis from the reduction of the enolase activity results in activation of NLR-involved immune responses which further influences primary metabolism and plant growth, highlighting the complex interaction between primary metabolism and plant immunity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
希卡利是光完成签到,获得积分20
刚刚
刚刚
SciGPT应助SUN采纳,获得10
刚刚
1秒前
WerWu应助111采纳,获得10
2秒前
3秒前
5秒前
东华发布了新的文献求助10
5秒前
Kk发布了新的文献求助10
5秒前
香蕉觅云应助杰克采纳,获得10
6秒前
Lena发布了新的文献求助10
7秒前
8R60d8完成签到,获得积分0
7秒前
8秒前
勤劳落雁关注了科研通微信公众号
11秒前
哈哈发布了新的文献求助10
11秒前
领导范儿应助安详的夏之采纳,获得10
12秒前
rafa完成签到,获得积分10
12秒前
lanzai完成签到 ,获得积分10
13秒前
14秒前
15秒前
超超发布了新的文献求助10
15秒前
16秒前
WZ发布了新的文献求助10
17秒前
17秒前
serafinaX发布了新的文献求助10
19秒前
科研通AI2S应助tianya采纳,获得10
19秒前
现代飞鸟发布了新的文献求助10
19秒前
20秒前
21秒前
科研通AI2S应助满眼星辰采纳,获得10
21秒前
杰克发布了新的文献求助10
23秒前
现代飞鸟完成签到,获得积分10
25秒前
27秒前
刘口水完成签到 ,获得积分10
28秒前
香蕉觅云应助超超采纳,获得10
28秒前
WZ关闭了WZ文献求助
29秒前
顾矜应助花开不败采纳,获得10
32秒前
在水一方应助东华采纳,获得10
32秒前
Bzq应助内向的凤凰采纳,获得10
33秒前
高分求助中
Manual of Clinical Microbiology, 4 Volume Set (ASM Books) 13th Edition 1000
Sport in der Antike 800
De arte gymnastica. The art of gymnastics 600
少脉山油柑叶的化学成分研究 530
Electronic Structure Calculations and Structure-Property Relationships on Aromatic Nitro Compounds 500
Berns Ziesemer - Maos deutscher Topagent: Wie China die Bundesrepublik eroberte 500
Stephen R. Mackinnon - Chen Hansheng: China’s Last Romantic Revolutionary (2023) 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2417096
求助须知:如何正确求助?哪些是违规求助? 2109494
关于积分的说明 5334666
捐赠科研通 1836610
什么是DOI,文献DOI怎么找? 914741
版权声明 561068
科研通“疑难数据库(出版商)”最低求助积分说明 489200