纳米载体
两亲性
化学
药物输送
环糊精
细胞毒性
谷胱甘肽
靶向给药
组合化学
生物物理学
纳米技术
有机化学
聚合物
共聚物
材料科学
生物化学
体外
酶
生物
作者
Hui Liu,Jian Chen,Xiufang Li,Zhiwei Deng,Peiru Gao,Jianbin Li,Tao Ren,Ling Huang,Yanjing Yang,Shian Zhong
标识
DOI:10.1016/j.colsurfb.2019.05.011
摘要
A novel glutathione-responsive (GSH-responsive) star-like amphiphilic polymer (C12H25)14-β-CD-(S-S-mPEG)7 (denoted as CCSP) was designed for efficient antitumor drug delivery. The amphiphilic β-cyclodextrin (β-CD) self-polymerize in water to form a sphere with a diameter of 40–50 nm. The secondary hydroxyl groups of β-CD were modified by dodecyl to form a hydrophobic core and the primary hydroxyl groups of β-CD were decorated with PEG through disulfide bond to form a hydrophilic shell. Since the hydrophobic cavity of β-CD was maintained, the hydrophobic core formed by dodecyl as well as cavity of β-CD provided CCSP with a loading content as high as 39.6 wt%. Importantly, [email protected] exhibited low drug leakage and negligible cytotoxicity in non-reductive physiological environment, while it showed rapid release and high cytotoxicity in reductive tumorous environment via the breakage of disulfide bond. In view of the above-mentioned advantages of [email protected] nanocarriers such as high loading content, proper size, favorable stimulus-response release performance and low leakage, it is believed that CCSP may offer great potential to be used as an intelligent nanocarrier for anticancer drug delivery.
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