砷
生物转化
化学
药理学
体内
氧化应激
脱氧鸟苷
毒性
新陈代谢
代谢途径
砷毒性
生物化学
酶
生物
生物技术
有机化学
作者
Pengcheng Tu,Jingchuan Xue,Xiaoming Bian,Liang Chi,Bei Gao,Jiapeng Leng,Hongyu Ru,Thomas J. Knobloch,Christopher M. Weghorst,Kun Lü
标识
DOI:10.1016/j.taap.2019.114633
摘要
Arsenic in drinking water is a worldwide public health problem due to its pathogenic induction of oxidative stress in various organ systems. Phytochemicals present in polyphenolic-rich fruits such as black raspberries (BRBs) have diverse health benefits, including antioxidation and modulation of enzymes in xenobiotic metabolism. We used a mouse model combined with a standardized BRB-rich diet to investigate the impact of BRB consumption on arsenic biotransformation. We observed a significant reduction of urinary 8-oxo-2′-deoxyguanosine (8-oxodG) together with elevated levels of methylation and urinary excretion of arsenic in mice concurrently fed BRBs upon arsenic exposure. Moreover, enzyme expression and liver metabolites involved in arsenic metabolism were found to be different between mice on BRB and control diets with arsenic exposure. These data indicate that BRB consumption affected arsenic biotransformation in vivo likely via alterations in related metabolic enzymes and cofactors, providing evidence on reduction of arsenic toxicity by consumption of BRBs.
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