Mechanisms of adaptor protein p66Shc and endocannabinoid system in renal injury of chronic intermittent hypoxia

Due to the special pathophysiological change of chronic intermittent hypoxia (CIH), obstructive sleep apnea (OSA) causes systemic inflammatory response and oxidative stress, which eventually leads to multiple target organ damage.OSA can directly lead to hypoxia in the kidney, which results in kidney damage and increases the risk of secondary chronic kidney disease in untreated OSA patients.By promoting the production of reactive oxygen species and inhibiting the expression of antioxidant enzymes, adapter protein p66Shc, as an oxidoreductase, can participate in the pathogenesis of kidney injury.In various kidney diseases, the expression of membrane receptor CB1R in endocannabinoid system increases, which activates inflammatory cascade reaction and promotes the production of inflammatory factors.This article reviews the possible mechanisms of p66Shc and endocannabinoid system in CIH-induced renal injury. Key words: Chronic intermittent hypoxia; p66Shc; Reactive oxygen species; Kidney damage; Endocannabinoid system