化学
铜
荧光
一氧化氮
荧光寿命成像显微镜
有机化学
光学
物理
作者
Xiaoyue Hu,Xiaolin Zhang,Hong-Lei Song,Chunying Duan,Yongming Bao,Qin Tang
出处
期刊:Tetrahedron
[Elsevier]
日期:2012-09-30
卷期号:68 (39): 8371-8375
被引量:13
标识
DOI:10.1016/j.tet.2012.04.002
摘要
Abstract A novel copper(II) complex CuQNE with a naphthalimide-containing ligand was synthesized as a fluorescent sensor of nitric oxide (NO). It featured eightfold fluorescent enhancement toward NO from a dark-background with the detection limit of NO about 1 nM in aqueous solution. The fluorescence response of the CuQNE was specific for NO, the presence of other reactive oxygen species (ROS) and reactive nitrogen species (RNS) did not interfere with the detection of NO in aqueous solution. LC–MS and IR spectra of the reaction mixture both demonstrated that the fluorescence enhancement was possibly attributed to an NO-induced nitrosation of the amino group. Confocal fluorescence images of MCF-7 cells suggested that CuQNE could be applied for monitoring intracellular NO.
科研通智能强力驱动
Strongly Powered by AbleSci AI