Dose optimisation of linezolid in critically ill patients based on a population pharmacokinetic model: A two-centre prospective interventional study

Interventions by clinical pharmacists reduced the incidence of LIT and other ADRs. Implementation of model-informed precision dosing (MIPD) for linezolid markedly increased the C_min and AUC₂₄/MIC rates within the target range. We recommend MIPD-guided linezolid dose reduction for patients with renal impairment.