Association between the Systemic Immune-Inflammation Index and Prostate Cancer

AbstractThe systemic immune-inflammation index (SII) is a novel and integrated marker that has not been studied with prostate cancer. We aimed to ascertain the association between SII levels and prostate cancer. We utilized data from the 1999–2010 cycles of the National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression analyses were conducted to evaluate the relationship between SII and prostate cancer. Additionally, subgroup analyses stratified by age, BMI, history of hypertension and diabetes were performed. A total of 8,020 participants were included in our analysis. After full adjustment, SII was associated with a 7% increased risk of prostate cancer (OR 1.07, 95% CI 0.99–1.15, p = 0.094). We further categorized SII values into three segments and found that individuals in the highest SII group had a 33% increased risk of prostate cancer than those in the tertile 1 group (OR 1.33; 95% CI 1.01–1.81; p = 0.044; P for trend = 0.046). In addition, a higher SII level was associated with a 137% increased risk of prostate cancer in the diabetes subgroup (OR 2.37; 95% CI 1.08–5.21; p = 0.031). The current study suggested that SII was positively associated with increased risks of prostate cancer. The SII might be an easily accessible indicator for identifying prostate cancer. AcknowledgmentsZhumei Luo, Wei Wang and Liyuan Xiang contributed equally to this work and should be considered as co-first author.Ethical ApprovalWritten informed consent was provided for each participant and the National Center for Health Statistics Research Ethics Review Board approved the projectAuthors’ ContributionsLZ and WW proposed the conception and design. LZ and WW provided administrative support. LZ, WW, and XL supplied the study materials. LZ and JT collected and assessed the data. XL analyzed the data. All authors contributed to the article and approved the submitted version.Informed consentThe data of participants were obtained from the public dataset NHANES in an anonymous form. Thus, additional consents were waived in the present study.Disclosure StatementThe authors declare that they have no conflict of interest.Data Availability StatementThe datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found at: NHANES.Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article.