Exploring atherosclerosis imaging with contrast-enhanced MRI using PEGylated ultrasmall iron oxide nanoparticles

磁共振成像 医学 病变 氧化铁纳米粒子 荧光寿命成像显微镜 分子成像 放射科 生物医学工程 材料科学 纳米颗粒 荧光 病理 体内 纳米技术 光学 物理 生物技术 生物
作者
Ruru Zhang,Kuan Lu,Xiao Li,Xuelan Hu,Wu Cai,Linjiang Liu,Yan Liu,Weihua Li,Hui Zhou,Zhiyuan Qian,Sixia Wang,Can Chen,Jianfeng Zeng,Mingyuan Gao
出处
期刊:Frontiers in Bioengineering and Biotechnology [Frontiers Media]
卷期号:11 被引量:9
标识
DOI:10.3389/fbioe.2023.1279446
摘要

Plaque rupture is a critical concern due to its potential for severe outcomes such as cerebral infarction and myocardial infarction, underscoring the urgency of noninvasive early diagnosis. Magnetic resonance imaging (MRI) has gained prominence in plaque imaging, leveraging its noninvasiveness, high spatial resolution, and lack of ionizing radiation. Ultrasmall iron oxides, when modified with polyethylene glycol, exhibit prolonged blood circulation and passive targeting toward plaque sites, rendering them conducive for MRI. In this study, we synthesized ultrasmall iron oxide nanoparticles of approximately 3 nm via high-temperature thermal decomposition. Subsequent surface modification facilitated the creation of a dual-modality magnetic resonance/fluorescence probe. Upon intravenous administration of the probes, MRI assessment of atherosclerotic plaques and diagnostic evaluation were conducted. The application of Flash-3D sequence imaging revealed vascular constriction at lesion sites, accompanied by a gradual signal amplification postprobe injection. T1-weighted imaging of the carotid artery unveiled a progressive signal ratio increase between plaques and controls within 72 h post-administration. Fluorescence imaging of isolated carotid arteries exhibited incremental lesion-to-control signal ratios. Additionally, T1 imaging of the aorta demonstrated an evolving signal enhancement over 48 h. Therefore, the ultrasmall iron oxide nanoparticles hold immense promise for early and noninvasive diagnosis of plaques, providing an avenue for dynamic evaluation over an extended time frame.
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