转鼓
羧化
化学
亲核细胞
试剂
镁
芳基
组合化学
有机化学
催化作用
烷基
作者
Yongtao Yan,Jianjun Hao,Fenfen Xie,Feng Han,Lin‐Hai Jing,Pan Han
标识
DOI:10.1021/acs.joc.3c01632
摘要
Magnesium-mediated reductive carboxylation of p-QMs with CO2 via an Umpolung strategy has been developed, which can be used for the preparation of various aryl acetic acids. This protocol featured high atom economy, mild conditions, and operational simplicity. The creation of this Umpolung carboxylation of p-QMs will unprecedentedly extend the application of p-QMs to nucleophilic reagents.
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