遗传异质性
精神病理学
病因学
遗传变异
遗传变异
生物
表型
遗传相关
计算生物学
进化生物学
心理学
遗传学
临床心理学
精神科
基因型
基因
作者
Harvey Wang,Martin Alda,Thomas Trappenberg,Abraham Nunes
标识
DOI:10.1097/ypg.0000000000000304
摘要
An improved understanding of genetic etiological heterogeneity in a psychiatric condition may help us (a) isolate a neurophysiological ‘final common pathway’ by identifying its upstream genetic origins and (b) facilitate characterization of the condition’s phenotypic variation. This review aims to identify existing genetic heterogeneity measurements in the psychiatric literature and provides a conceptual review of their mechanisms, limitations, and assumptions. The Scopus database was searched for studies that quantified genetic heterogeneity or correlation of psychiatric phenotypes with human genetic data. Ninety studies were included. Eighty-seven reports quantified genetic correlation, five applied genomic structural equation modelling, three evaluated departure from the Hardy–Weinberg equilibrium at one or more loci, and two applied a novel approach known as MiXeR. We found no study that rigorously measured genetic etiological heterogeneity across a large number of markers. Developing such approaches may help better characterize the biological diversity of psychopathology.
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