赤藓糖醇
雅罗维亚
甘油
酵母
拉伤
阿拉伯糖醇
产量(工程)
生物化学
化学
甘露醇
基质(水族馆)
食品科学
生物
发酵
材料科学
木糖醇
冶金
解剖
生态学
作者
Mateusz Szczepańczyk,Dorota A. Rzechonek,Adam Dobrowolski,Aleksandra M. Mirończuk
出处
期刊:Molecules
[MDPI AG]
日期:2021-12-13
卷期号:26 (24): 7549-7549
被引量:9
标识
DOI:10.3390/molecules26247549
摘要
The unconventional yeast Yarrowia lipolytica is used to produce erythritol from glycerol. In this study, the role of the erythrose reductase (ER) homolog YALI0B07117g in erythritol synthesis was analyzed. The deletion of the gene resulted in an increased production of mannitol (308%) and arabitol (204%) before the utilization of these polyols began. The strain overexpressing the YALI0B07117g gene was used to increase the erythritol yield from glycerol as a sole carbon source in batch cultures, resulting in a yield of 0.4 g/g. The specific consumption rate (qs) increased from 5.83 g/g/L for the WT strain to 8.49 g/g/L for the modified strain and the productivity of erythritol increased from 0.28 g/(L h) for the A101 strain to 0.41 g/(L h) for the modified strain. The application of the research may prove positive for shortening the cultivation time due to the increased rate of consumption of the substrate combined with the increased parameters of erythritol synthesis.
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