RNA编辑
计算生物学
生物
核糖核酸
人类蛋白质组计划
阿达尔
肌苷
剧目
蛋白质组
进化生物学
遗传学
基因
腺苷
蛋白质组学
生物化学
物理
声学
作者
Orshay Gabay,Yoav Shoshan,Eli Kopel,Udi Ben-Zvi,Tomer Mann,Noam Bressler,Roni Cohen‐Fultheim,Amos A Schaffer,Shalom Hillel Roth,Ziv Tzur,Erez Y. Levanon,Eli Eisenberg
标识
DOI:10.1038/s41467-022-28841-4
摘要
RNA editing by adenosine deaminases changes the information encoded in the mRNA from its genomic blueprint. Editing of protein-coding sequences can introduce novel, functionally distinct, protein isoforms and diversify the proteome. The functional importance of a few recoding sites has been appreciated for decades. However, systematic methods to uncover these sites perform poorly, and the full repertoire of recoding in human and other mammals is unknown. Here we present a new detection approach, and analyze 9125 GTEx RNA-seq samples, to produce a highly-accurate atlas of 1517 editing sites within the coding region and their editing levels across human tissues. Single-cell RNA-seq data shows protein recoding contributes to the variability across cell subpopulations. Most highly edited sites are evolutionary conserved in non-primate mammals, attesting for adaptation. This comprehensive set can facilitate understanding of the role of recoding in human physiology and diseases.
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