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研友_5Zl9D8
Lv7
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4665 积分
2020-04-09 加入
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Advancements in dual-target inhibitors of PI3K for tumor therapy: Clinical progress, development strategies, prospects
10天前
已完结
A comprehensive review of small molecules targeting PI3K pathway: Exploring the structural development for the treatment of breast cancer
10天前
已完结
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts
11天前
已完结
Allosteric PI3K-alpha inhibition overcomes on-target resistance to orthosteric inhibitors mediated by secondary PIK3CA mutations
11天前
已完结
Discovery and clinical proof-of-concept of RLY-2608, a first-in-class mutant-selective allosteric PI3Ka inhibitor that decouples anti-tumor activity from hyperinsulinemia
11天前
已完结
Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases
13天前
已完结
Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition
13天前
已完结
Class 1 PI3K Clinical Candidates and Recent Inhibitor Design Strategies: A Medicinal Chemistry Perspective
13天前
已完结
Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ
13天前
已完结
Discovery of Novel Phosphoinositide-3-Kinase α Inhibitors with High Selectivity, Excellent Bioavailability, and Long-Acting Efficacy for Gastric Cancer
13天前
已完结
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