Lv11
40 积分 2024-06-17 加入
Rational discovery of molecular glue degraders based on block chemistry
3小时前
已完结
Discovery of MKP10241, a Novel Small Molecule Targeting the GPR119/Incretin Axis to Treat Metabolic Disorders
2天前
已完结
Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer
15天前
已完结
Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo
15天前
已完结
Design, synthesis and biological evaluation of (E)-4-(2-((1H-indol-5-yl) methylene) hydrazineyl)-5,6,7,8-tetrahydropyrido [4',3':4,5] thieno[2,3-d] pyrimidine derivatives as Arf1-GEFs inhibitors for the treatment of colon cancer
15天前
已完结
Discovery of Novel, Potent, Selective, and Orally Available DGKα Inhibitors for the Treatment of Tumors
1个月前
已完结
Discovery of Potent and Selective Pyrrolo[2,3-d]pyrimidine Derivatives as Fourth-Generation EGFR Inhibitors Targeting Triple Mutations
1个月前
已完结
The Discovery of RP-2119: A Potent, Selective, and Orally Bioavailable Polθ ATPase Inhibitor
1个月前
已完结
Discovery of APS03118, a Potent and Selective Next-Generation RET Inhibitor with a Novel Kinase Hinge Scaffold
1个月前
已完结
MALT1 Inhibitors and Degraders: Strategies for NF-κB-Driven Malignancies
1个月前
已完结
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