Lv31
366 积分 2025-11-14 加入
Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN
1小时前
待确认
Structural rationalization of GSPT1 and IKZF1 degradation by thalidomide molecular glue derivatives
1小时前
已完结
Targeting Bromodomain and Extraterminal Proteins for Drug Discovery: From Current Progress to Technological Development
2个月前
已完结
Dual‐target inhibitors of bromodomain and extra‐terminal proteins in cancer: A review from medicinal chemistry perspectives
2个月前
已完结
Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer
2个月前
已完结
Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer Treatment
3个月前
已完结
Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma
3个月前
已完结
The therapeutic antibody sacituzumab induces trophoblast cell-surface antigen-2 conformational rearrangement
7个月前
已完结
Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders
9个月前
已完结
Discovery of a Potent and Selective GSPT1 Molecular Glue Degrader for the Treatment of Castration-Resistant Prostate Cancer
9个月前
已完结
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