Lv4
694 积分 2024-09-26 加入
Replacement of sulfonamide by sulfoximine within a helicase-primase inhibitor with restricted flexibility
26天前
已完结
Novel selective agents for the degradation of AR/AR-V7 to treat advanced prostate cancer
1个月前
已完结
Butein suppresses pancreatic cancer progression by downregulating CDK2 and disrupting CDK2/CyclinA2 interaction
1个月前
已关闭
AUTX-703, A Novel and Potent KAT2A and KAT2B Proteint Degrader, Induces Profound and Persistent Cell State Differentiation and Inhibits Growth in SCLC Model Systems
1个月前
已关闭
Discovery and Development of a Highly Potent, Orally Bioavailable Estrogen Receptor Full Antagonist and Degrader: Giredestrant (GDC-9545) for Estrogen Receptor-Positive Breast Cancer
1个月前
已关闭
Discovery of A First-in-class Protein Arginine Methyltransferase 1 (PRMT1) Degrader for Nonenzymatic Functions Studies
2个月前
已完结
Gossypol suppresses tumorigenesis through inhibition of multiple deubiquitinating enzymes
2个月前
已完结
Discovery and Optimization of Orally Bioavailable Heterobifunctional Degraders of KAT2A/B for the Treatment of Cancer
2个月前
已完结
Structural insights into IL-31 signaling inhibition by a neutralizing antibody
3个月前
已完结
Anti-tumor effects of Skp2 inhibitor AAA-237 on NSCLC by arresting cell cycle at G0/G1 phase and inducing senescence
4个月前
已完结
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