Lv11
40 积分 2025-06-10 加入
Recent Developments in Cyclin-Dependent Kinase (CDK) PROTAC in Cancer Therapy
1小时前
待确认
Exploiting targeted degradation of cyclins and cyclin-dependent kinases for cancer therapeutics: a review
3天前
已完结
Design, Biological Characterization, and Discovery of Capromorelin Derivatives as Oral Growth Hormone Secretagogue Receptor Type 1a Agonist for the Treatment of Growth Hormone Deficiency
5天前
已完结
Novel Carbamate-Based o-aminobenzamide Derivatives as Potent Antigastric Carcinoma Agents via Disrupting NAD+ Salvage Synthesis
1个月前
已完结
Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy
1个月前
已完结
Formal γ−C−H Functionalization of Cyclobutyl Ketones: Synthesis of cis‐1,3‐Difunctionalized Cyclobutanes
1个月前
已完结
CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers
1个月前
已完结
Structure-Based Optimization of Imidazopyridine Derivatives as Selective and Orally Bioavailable Phosphodiesterase 10A Inhibitors with Reduced Blood–Brain Barrier Penetration for the Treatment of Idiopathic Pulmonary Fibrosis
2个月前
已完结
Discovery of Highly Potent and Orally Available CCNK Molecular Glue Degraders as Broad-Spectrum Antitumor Agents
2个月前
已完结
Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1
2个月前
已完结
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