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528 积分 2024-01-04 加入
Ternary Complex Geometry and Lysine Positioning Guide the Generation of PROTAC-Induced Degradable Complexes
1小时前
已完结
Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN
10天前
已完结
Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
10天前
已完结
Abstract A057: Therapeutic efficacy of selective CDK7 inhibition in pancreatic cancer mediated by induction of R-loop formation, DNA replication stress and genomic instability
10天前
已关闭
Disrupting the RNA polymerase II transcription cycle through CDK7 inhibition ameliorates inflammatory arthritis
10天前
已完结
Abstract 7004: CT7439 an oral first-in class selective CDK12 and 13 inhibitor and cyclin K degrader: Profiling activity and combination efficacy in an ovarian cancer model
10天前
已完结
Abstract A026: Discovery of potent and selective CDK2 molecule glue degraders for the treatment of HR+/HER2- breast cancer, and CCNE1 amplified tumors
10天前
已完结
Synthesis and Some Reactions of 2-(2-Aminoanilino)cyclohepta[b]pyrroles: Leading to 5H-Cyclohepta[1′,2′: 4,5]pyrrolo[2,3-b][1,5]benzodiazepine, a Novel 20π Antiaromatic System, and Cydohepta[1′,2′: 4,5] pyrrolo[1,2-a]benzimidazoles
14天前
已完结
Targeted protein degradation of HSP90 and associated proteins for cancer therapy via PROTACs and beyond
14天前
已完结
Continuous evolution of compact protein degradation tags regulated by selective molecular glues
14天前
已完结
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