Lv12
70 积分 2022-12-12 加入
A Rationally Designed Novel Bifunctional Human TNF-- and Janus Kinase-Targeted soloMER Drug Conjugate (SDC) with a Neutrophil Elastase Cleavable Linker Delivering Inflammation Site-Specific Release of Payload
1天前
已完结
Beyond Target Occupancy in Triple-Negative Breast Cancer: A Medicinal Chemistry Perspective on Modality-Guided Design for Durable Network Control
13天前
已完结
Discovery Process of Enlicitide, a Highly Engineered Macrocyclic Peptide Therapeutic, through Issue-Driven Fragment-Based Synthetic Assembly and SAR
25天前
已完结
De novo design of miniproteins targeting GPCRs
29天前
已完结
Use of Human Dose Prediction Metrics to Enable Discovery of AZD3470, an MTA-Cooperative PRMT5 Inhibitor in Clinical Evaluation
29天前
已完结
Synthesis of substituted tetrahydronaphthalenes by manganese(III), cerium(IV), and iron(III) oxidation of substituted diethyl .alpha.-benzylmalonates in the presence of olefins
1个月前
已完结
Organosilane-mediated free radical cyclization reactions employing carbonyl traps
1个月前
已完结
Discovery of Novel N-Glycoside and Non-Glycoside hSGLT2 Inhibitors for the Treatment of Type 2 Diabetes Mellitus
1个月前
已完结
Preclinical characterization of TOS-358, a potent and selective covalent inhibitor of wild-type and mutant PI3Kα with superior anticancer activity
1个月前
已完结
MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design
1个月前
已完结
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