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38 积分 2025-10-28 加入
Discovery of Novel SHP2 ATTEC Degraders against Pancreatic Ductal Adenocarcinoma Harboring KRAS(G12D) Mutations
1天前
待确认
Degron-independent recruitment of KAT2A expands the target space of CRBN molecular glues
22天前
已完结
Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3
1个月前
已完结
Lessons learned in linking PROTACS from discovery to the clinic
1个月前
已完结
Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy
4个月前
已完结
Overexpression in Escherichia coli and purification of human fibroblast growth factor (FGF-2)
6个月前
已完结
Design, Synthesis, and Biological Evaluation of the First Novel Macrocycle-Based FGFR Inhibitors That Overcome Clinically Acquired Resistance
6个月前
已完结
Covalent Recruitment of NEDD4 for Targeted Protein Degradation: Rational Design of Small Molecular Degraders
8个月前
已完结
Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2
9个月前
已完结
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