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370 积分 2026-08-17 加入
Impact of Nonspecific Binding to Membrane Vesicles on Unbound IC50 Estimation for P-glycoprotein and BCRP Inhibitors and Implications for DDI Risk Assessment
18天前
已关闭
Radioactive ADME Demonstrates ARV-110’s High Druggability Despite Low Oral Bioavailability
1个月前
已完结
Rapid equilibrium dialysis, ultrafiltration or ultracentrifugation? Evaluation of methods to quantify the unbound fraction of substances in plasma
1个月前
已完结
Breaking the 1% unbound threshold: An IQ consortium whitepaper on the evaluation of plasma protein binding of highly bound compounds
1个月前
已完结
A framework for plasma protein binding: Comparing methods for diverse small molecules and adapting for novel modalities
1个月前
已完结
A permeability assay adapted for the assessment of very poorly permeable compounds in the bRo5 space
1个月前
已完结
Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives
1个月前
已完结
Overcoming Challenges in the Metabolism of Peptide Therapeutics: Strategies and Case Studies for Clinical Success
1个月前
已完结
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