Lv5
1030 积分 2023-12-06 加入
Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules
7个月前
已完结
Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand
7个月前
已完结
Rational design of VHL-recruiting KRASG12C proteolysis-targeting chimeras based on molecular dynamics simulation
7个月前
已完结
Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1
8个月前
已完结
Biphenyl-based small molecule inhibitors: Novel cancer immunotherapeutic agents targeting PD-1/PD-L1 interaction
9个月前
已完结
Discovery of novel resorcinol biphenyl ether-based macrocyclic small molecules as PD-1/PD-L1 inhibitors with favorable pharmacokinetics for cancer immunotherapy
9个月前
已完结
Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents
9个月前
已完结
Design of Biphenyl‐Type Programmed Cell Death‐Ligand 1 Inhibitors Using 3D‐QSAR, Molecular Docking, and Molecular Dynamics Simulation
9个月前
已完结
C2-Symmetrical Terphenyl Derivatives as Small Molecule Inhibitors of Programmed Cell Death 1/Programmed Death Ligand 1 Protein–Protein Interaction
9个月前
已完结
Nonsymmetrically Substituted 1,1′-Biphenyl-Based Small Molecule Inhibitors of the PD-1/PD-L1 Interaction
9个月前
已完结
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