Lv1
78 积分 2025-01-29 加入
Targeting lactate with a GLUT1 inhibitor reverses PARP inhibitor resistance in ovarian cancer
23天前
已关闭
PARP1-mediated PARylation of TEAD4 stabilizes the YAP1-TEAD4 complex and promotes growth and immune evasion in breast cancer cells
25天前
已完结
Mitigating T cell DNA damage during PARP inhibitor treatment enhances antitumor efficacy
25天前
已完结
Design of soluble Notch agonists that drive T cell development and boost immunity
1个月前
已完结
Targeting of SOS1: from SOS1 Activators to Proteolysis Targeting Chimeras
1个月前
已完结
CD36-mediated endocytosis of proteolysis-targeting chimeras
1个月前
已完结
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity
3个月前
已完结
Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation
3个月前
已完结
Discovery of BWA-522, a First-in-Class and Orally Bioavailable PROTAC Degrader of the Androgen Receptor Targeting N-Terminal Domain for the Treatment of Prostate Cancer
3个月前
已完结
Bifunctional small molecules that mediate the degradation of extracellular proteins
5个月前
已完结
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