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48 积分 2025-05-24 加入
Structure-based design, synthesis, and evaluation of inhibitors with high selectivity for PARP-1 over PARP-2
2小时前
待确认
Artificial intelligence in drug development
4个月前
已完结
Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir
5个月前
已完结
Exploration of SARS-CoV-2 3CLpro Inhibitors by Virtual Screening Methods, FRET Detection, and CPE Assay
7个月前
已完结
Topotecan induces apoptosis via ASCT2 mediated oxidative stress in gastric cancer
7个月前
已完结
Preclinical Characterization of AZD9574, a Blood–Brain Barrier Penetrant Inhibitor of PARP1
9个月前
已完结
Design, Synthesis, and Pharmacodynamic Evaluation of Highly Selective PARP1 Inhibitors with Brain Penetrance
9个月前
已完结
Discovery and Pharmacological Evaluation of Potent and Highly Selective PARP1 Inhibitors
9个月前
已完结
Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor
9个月前
已完结
Discovery of the PARP (poly ADP-ribose polymerase) inhibitor 2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-1H-benzo[d]imidazole-4-carboxamide for the treatment of cancer
10个月前
已关闭
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