Lv7
4200 积分 2022-09-16 加入
63881 Oral IL-17A Small Molecule Inhibitors Designed by Generative AI with Biologics-Like Potency for Psoriasis Treatment
5天前
已完结
Deuterium in drug discovery: progress, opportunities and challenges
11天前
已完结
Small molecule interleukin (IL) 17A/A antagonists and antibodies blocking both IL17A/A and IL17A/F demonstrate equivalent degrees of efficacy in preclinical models of skin and joint inflammation
12天前
已完结
Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers
2个月前
已完结
Preclinical Toxicology Supply for a Complex API Enabled by Asymmetric Catalysis and Rapid Chemical Development: IL-17A Inhibitor LY3509754
2个月前
已完结
Strategies to Mitigate CYP450 Inhibition
4个月前
已完结
Differential Pharmacodynamic Effects on Psoriatic Biomarkers by Guselkumab Versus Secukinumab Correlate with Long-Term Efficacy: An ECLIPSE Substudy
5个月前
已完结
Guselkumab Reduces Disease- and Mechanism-Related Biomarkers More Than Adalimumab in Patients with Psoriasis: A VOYAGE 1 Substudy
5个月前
已完结
A Novel Small Molecule Allosteric Inhibitor of IL-17A from a DNA-Encoded Library
6个月前
已完结
Exposure-Effect Relationships in Established Rat Adjuvant-Induced and Collagen-Induced Arthritis: A Translational Pharmacokinetic-Pharmacodynamic Analysis
7个月前
已完结
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