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3720 积分 2023-11-15 加入
PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2V617F-Mutant MPN
5小时前
待确认
Development of Resistance to Type II JAK2 Inhibitors in MPN Depends on AXL Kinase and Is Targetable
6小时前
待确认
Discovery of Highly Selective and Potent Macrocyclic JAK2 Inhibitors for the Treatment of MPNs
6小时前
待确认
The Pharmacology of the SLC15A4 ‐ TASL Complex, an Emerging Target for the Treatment of Lupus
3天前
已完结
Discovery of novel indole derivatives as LRH-1 antagonists for the treatment of castration resistant prostate cancer
4天前
已完结
Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket
4天前
已完结
New High-Throughput Screen Discovers Novel Ligands of Full-Length Nuclear Receptor LRH-1
4天前
已完结
Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias
4天前
已完结
Application of Bioisosteres in the Design and Discovery of FDA-Approved Drugs and Advanced Clinical Candidates
4天前
已完结
Design and Synthesis of Type-A Proanthocyanidin Derivatives as JAK2 Activators to Protect against Chemotherapy-Induced Myelosuppression
4天前
已完结
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