Lv11
10 积分 2025-07-07 加入
Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays
3小时前
已完结
An analysis of the attrition of drug candidates from four major pharmaceutical companies
3天前
已完结
Can the pharmaceutical industry reduce attrition rates?
3天前
已完结
Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors
6天前
已完结
Application of the Relative Activity Factor Approach in Scaling from Heterologously Expressed Cytochromes P450 to Human Liver Microsomes: Studies on Amitriptyline as a Model Substrate
6天前
已关闭
Discussion
7天前
已完结
Comparison between Cytochrome P450 (CYP) Content and Relative Activity Approaches to Scaling from cDNA-Expressed CYPs to Human Liver Microsomes: Ratios of Accessory Proteins as Sources of Discrepancies between the Approaches
7天前
已关闭
In Vitro-In Vivo Extrapolation and Scaling Factors for Clearance of Human and Preclinical Species with Liver Microsomes and Hepatocytes
19天前
已完结
Phenotyping of CYP450 in human liver microsomes using the cocktail approach
19天前
已完结
(–)-N-3-Benzylphenobarbital Is Superior to Omeprazole and (+)-N-3-Benzylnirvanol as a CYP2C19 Inhibitor in Suspended Human Hepatocytes
27天前
已完结
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