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A Framework for Optimized Reaction Phenotyping of the Seven Major Hepatic CYP Isoforms in Human Liver Microsomes Using Six Mechanism-Based Inactivators and One Reversible Inhibitor
6天前
已关闭
Characterization and Applications of Permeabilized Hepatocytes in Drug Discovery
20天前
已完结
Addressing the challenges of determining fraction metabolized for low turnover drugs – An update from the quantitative fraction metabolized working group of the IQ consortium
1个月前
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Approach to Improve Compound Recovery in a High-Throughput Caco-2 Permeability Assay Supported by Liquid Chromatography–Tandem Mass Spectrometry
1个月前
已完结
A Systematic Evaluation of Solubility Enhancing Excipients to Enable the Generation of Permeability Data for Poorly Soluble Compounds in Caco-2 Model
1个月前
已完结
In Vitro Reversible Enzyme Inhibition Assays to Predict Drug-Drug Interactions: Current State and Industry Perspective from the IQ Enzyme Inhibition Working Group
1个月前
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IQ-MPS Affiliate perspectives on blood-brain barrier microphysiological systems: Progress and challenges ahead
3个月前
已关闭
Applications of contemporary tools to measure plasma protein binding of targeted protein degraders
3个月前
已完结
In vitro-in vivo scaling of CYP-mediated metabolic clearance using a relative activity factor (RAF) approach
3个月前
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Drug-drug interaction by metabolites: Challenges and solutions during therapeutics innovation
3个月前
已关闭
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