Lv7
3210 积分 2021-12-28 加入
Discovery of a potent and selective small-molecule inhibitor of ubiquitin-specific peptidase 15 (USP15) for the treatment of breast cancer
2个月前
已完结
Structure based identification of novel 4,5,6,7-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one derivatives as nonacidic ATX inhibitors with promising antifibrotic effects
2个月前
已完结
Development of highly selective, low-toxicity and orally available Mcl-1 inhibitors based on 3,5-dimethyl-4-sulfonimide-1H-pyrrole scaffold via P2/P3 dual pocket binding optimization
2个月前
已完结
Discovery of novel N-heterocycle-fused deoxypodophyllotoxin analogues as dual tubulin/PARP1 inhibitors for cancer treatment
2个月前
已完结
Structure-guided design of broad-spectrum inhibitors of coronaviral proteases embodying a 1,3,2-oxazaphospholidin-3-one scaffold as a versatile design element
2个月前
已完结
Discovery of Di-Amino Acid Antimicrobial Peptide Mimetics with Heteroatom-Incorporated Linkers for Potent Antibacterial Activity and Low Hemolytic Toxicity
2个月前
已完结
Breaking the barrier: Synergistic 2B4.4-1BB signaling potentiates HER2-CAR NK cells to penetrate and destroy ADCC-resistant tumors
4个月前
已关闭
TRIM21 drives glioblastoma malignancy via ubiquitination-mediated PDGFRA degradation
4个月前
已关闭
GAB3 suppresses lung adenocarcinoma progression by inhibiting the MAPK signaling and potentiating CD8+ T cell immunity
4个月前
已完结
Canagliflozin Is a Novel Androgen Receptor Pathway Inhibitor for Castrate-Sensitive and Castrate-Resistant Prostate Cancer
4个月前
已完结
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