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36 积分 2023-10-19 加入
Discovery of Pyrazoloquinazoline Analogues as Orally Bioavailable KRAS-G12D Inhibitors
6天前
已完结
Structure-Guided Development of Chemically Tailored Peptide Binders of RNF43/ZNRF3 to Enable Versatile Design of Membrane Protein-Targeting PROTACs
11天前
已完结
Estrogen Receptor β-Targeted Near-Infrared Inherently Fluorescent Probe: A Potent Tool for Estrogen Receptor β Research
29天前
已完结
Lessons learned in linking PROTACs from discovery to the clinic
30天前
已完结
Fragment-to-Lead Medicinal Chemistry Publications in 2024: A Tenth Annual Perspective
30天前
已完结
Identification of Novel pan-KRAS Inhibitors via Structure-Based Drug Design, Scaffold Hopping, and Biological Evaluation
1个月前
已完结
A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement
1个月前
已完结
ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation
1个月前
已完结
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony
1个月前
已完结
Isoform-specific function of NSD3 in DNA replication stress confers resistance to PARP inhibitors in prostate cancer
1个月前
已完结
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