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42 积分 2023-10-19 加入
Breakthrough in RAS targeting with pan-RAS(ON) inhibitors RMC-7977 and RMC-6236
1天前
待确认
Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor
6天前
已完结
Targeting the H/KRAS α4-β6-α5 Allosteric Lobe with Macrocyclic Peptides
6天前
已完结
Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models
15天前
已完结
The global, regional, and national burden of cancer, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023
19天前
已完结
Discovery of EGT710, an Oral Nonpeptidomimetic Reversible Covalent SARS-CoV‑2 Main Protease Inhibitor
24天前
已完结
Synthesis, biological evaluation, and mechanism investigation of multisubstituted quinazoline analogues as prospective inhibitors of KRAS G12D
25天前
已关闭
Discovery of Potent and Orally Bioavailable Pyrimidine Amide cGAS Inhibitors via Structure-Guided Hybridization
1个月前
已完结
Discovery of novel cGAS inhibitors based on natural flavonoids
1个月前
已完结
From KRASG12D to Pan-KRAS Inhibitors─A Journey Enabled by Synthetic Innovation and Structure-Based Drug Design
1个月前
已完结
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