Lv1
28 积分 2023-10-19 加入
Modular double-stranded DNA recognition defines specificity of the exonuclease TREX1 in cGAS-STING control
14天前
已完结
Discovery of highly potent and selective KRASG12C degraders by VHL-recruiting PROTACs for the treatment of tumors with KRASG12C-Mutation
22天前
已完结
Discovery of KRas G12C-IN-3 and Pomalidomide-based PROTACs as degraders of endogenous KRAS G12C with potent anticancer activity
22天前
已完结
Efficient targeted oncogenic KRASG12C degradation via first reversible-covalent PROTAC
22天前
已完结
Targeting Multiple KRAS Mutations with High-Affinity Macrocyclic Inhibitors: From Discovery to Preclinical Validation
27天前
已完结
Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor
28天前
已完结
Discovery of Selenium-Containing STING Agonists as Orally Available Antitumor Agents
28天前
已完结
Discovery of Fulzerasib (GFH925) for the Treatment of KRAS G12C-Mutated Solid Tumors
1个月前
已完结
Breakthrough in RAS targeting with pan-RAS(ON) inhibitors RMC-7977 and RMC-6236
1个月前
已完结
Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor
1个月前
已完结
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