Lv74
3530 积分 2022-07-29 加入
Design and Discovery of Novel Selective RET Inhibitors with High Central Nervous System Penetration, Enhanced Pharmacokinetics, and Pharmacodynamics
6小时前
已完结
In silico repurposing of FDA-approved drugs as multi-target inhibitors of glioblastoma
8天前
已完结
Discovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia
9天前
已完结
Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders
9天前
已完结
MD-4251: A First-in-Class Oral MDM2 Degrader Inducing Complete Tumor Regression with Single-Dose Administration
9天前
已完结
Hydrophobic tag-based protein degradation: Development, opportunity and challenge
13天前
已完结
Small-Molecule Hydrophobic Tagging: A Promising Strategy of Druglike Technology for Targeted Protein Degradation
13天前
已完结
First ATG101-recruiting small molecule degrader for selective CDK9 degradation via autophagy–lysosome pathway
13天前
已完结
Design and Synthesis of PARP/CDK6 Dual-Target Inhibitors Modulating of Wnt/β-Catenin Signaling Pathway for the Treatment of BRCA Wild-Type TNBC
13天前
已完结
Discovery of KIN-8741, a Highly Selective Type IIb c-Met Kinase Inhibitor with Broad Mutation Coverage and Quality Drug-Like Properties for the Treatment of Cancer
17天前
已完结
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