Lv75
4950 积分 2022-07-29 加入
Design, synthesis and biological evaluation of 2,4,5-trisubstituted 7H-Pyrrolo[2,3-d]pyrimidine derivatives as potent EGFR tyrosine kinase inhibitors against the C797S acquired resistance mutation
14天前
已完结
Development of APH003─a Highly Potent, Selective, and Orally Bioavailable IRAK4 PROTAC Degrader for the Treatment of Inflammatory Diseases
14天前
已完结
Beyond Pan-AKT Inhibition: Emerging Strategies for Isoform- and Mutant-Selective Targeting in Disease Therapy
24天前
已完结
Covalent Alkynylpyridopyrimidinones Targeting Cysteine 775 of the Epidermal Growth Factor Receptor Overcome Resistance to Current Therapies
29天前
已完结
Design, synthesis and biological evaluation of 2,4,5-trisubstituted 7H-Pyrrolo[2,3-d]pyrimidine derivatives as potent EGFR tyrosine kinase inhibitors against the C797S acquired resistance mutation
29天前
已关闭
Utilizing Molecular Dynamics and Mechanistic Pharmacokinetic Studies in the Design of Selective CDK2 Inhibitors
1个月前
已完结
Selective CDK2 Degradation via Noncanonical Recruitment
1个月前
已完结
Degradation of the TEAD·YAP/TAZ Transcription Factor Complex by Heterobifunctional Small Molecules That Bind to the TEAD Allosteric Lipid Pocket
1个月前
已完结
Integrating Machine Learning and Structure-Guided Discovery of a Novel Type II SYK Inhibitor for Treating Triple-Negative Breast Cancer
1个月前
已完结
On the Scope of DCAF1-Recruiting PROTACs Degrading Protein Kinases
1个月前
已完结
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