Lv5
1270 积分 2025-08-08 加入
Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia
3天前
已完结
Discovery of potent DNMT1 inhibitors against sickle cell disease using structural-based virtual screening, MM-GBSA and molecular dynamics simulation-based approaches
3天前
已完结
HsClpP-Engaging Selective Mitochondrial Pan-PDK Degraders for Cancer Therapy
11天前
已完结
Structure-Based Discovery of ( E )- and ( Z )-4-Oxobut-2-enoate Derivatives as Novel Covalent Pin1 Inhibitors with Antitumor Activity
11天前
已完结
Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via N-bc2S1P synthesis on neonatal skin
25天前
已完结
Discovery of Novel Spirocyclic MAT2A Inhibitors Demonstrating High In Vivo Efficacy in MTAP-Null Xenograft Models
25天前
已完结
Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
1个月前
已完结
Pharmacologic interrogation of USP28 cellular function in p53 signaling
1个月前
已完结
Human cytochrome P4502C8 metabolizes repaglinide to 4′-hydroxyrepaglinide, not 3′-hydroxyrepaglinide
1个月前
已关闭
Discovery of Novel Hsp90 Inhibitor-Evodiamine Derivative Conjugates as Potent and Orally Active Antitumor Agents for Colon Cancer Therapy
1个月前
已完结
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