Lv41
410 积分 2023-06-24 加入
Drug Design and Success of Prospective Mouse In Vitro–In Vivo Extrapolation (IVIVE) for Predictions of Plasma Clearance (CLp) from Hepatocyte Intrinsic Clearance (CLint)
3小时前
待确认
CYP3A Time-Dependent Inhibition Risk Assessment Validated with 400 Reference Drugs
13天前
已完结
Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
15天前
已完结
Prediction of in Vivo Nonlinear First-Pass Hepatic Metabolism of YM796 from in Vitro Metabolic Data
16天前
已完结
Discovery of FHD-286, a First-in-Class, Orally Bioavailable, Allosteric Dual Inhibitor of the Brahma Homologue (BRM) and Brahma-Related Gene 1 (BRG1) ATPase Activity for the Treatment of SWItch/Sucrose Non-Fermentable (SWI/SNF) Dependent Cancers
20天前
已完结
Preclinical Translational Physiologically Based Pharmacokinetic Modeling for Predicting Human Pharmacokinetics of PROTACs: Case Studies of Vepdegestrant (ARV-471) and Bavdegalutamide (ARV-110)
24天前
已关闭
In Vitro and In Vivo Mechanistic Studies toward Understanding the Role of 1-Aminobenzotriazole in Rat Drug-Drug Interactions
26天前
已完结
The Use of 1-Aminobenzotriazole in Differentiating the Role of CYPMediated First Pass Metabolism and Absorption in Limiting Drug Oral Bioavailability: A Case Study
27天前
已完结
ABT, Elacridar and Bile‐Duct Cannulated Rats: Tools to Understand Pharmacokinetics
27天前
已完结
The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia
27天前
已完结
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