Lv2
108 积分 2025-02-02 加入
X-ray Crystallography-Guided Discovery of a Potent Dual-Pocket Competitive SIRT5 Inhibitor against Sepsis-Associated AKI
1个月前
已完结
Structure–Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury
1个月前
已完结
Tu1727 MRT-6160, A VAV1-DIRECTED MOLECULAR GLUE DEGRADER, INHIBITS DISEASE PROGRESSION IN A T-CELL TRANSFER MEDIATED MURINE COLITIS MODEL CONCOMITANT WITH REDUCED CALPROTECTIN EXPRESSION
6个月前
已完结
P164 MRT-6160, a VAV1-directed molecular glue degrader, inhibits disease progression and inflammation in a T-cell transfer model of Colitis
6个月前
已完结
Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy
6个月前
已完结
Sirt5 in mediating endothelial and vascular dysfunction: a novel target in aging-related vascular diseases
6个月前
已完结
SIRT5 slows skeletal muscle ageing by alleviating inflammation
6个月前
已完结
SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1
6个月前
已完结
Sirt5 in mediating endothelial and vascular dysfunction: a novel target in aging-related vascular diseases
6个月前
已完结
Mitochondrial Sirtuins in Cancer: A Revisited Review from Molecular Mechanisms to Therapeutic Strategies
6个月前
已完结
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