Lv454
718 积分 2022-12-26 加入
A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice
28分钟前
已完结
APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease
4小时前
已完结
Neuronal ApoE4 stimulates C/EBPβ activation, promoting Alzheimer’s disease pathology in a mouse model
4小时前
已完结
Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models
5小时前
已完结
Prime Editing of Alzheimer’s Disease High-Risk APOE4 Allele by Brain-Directed Adeno-Associated Virus Vectors
5小时前
已完结
Effect of protective mutation on structure and dynamics of APOE: a molecular dynamics simulation study
6天前
已完结
AAVrh.10 Delivery of Novel APOE2-Christchurch Variant Suppresses Amyloid and Tau Pathology in Alzheimer’s Disease Mice
6天前
已完结
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes
6天前
已完结
REELIN-COLBOS (H3447R) in Colombian oldest-old individuals, a case series
6天前
已完结
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
6天前
已完结
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