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50 积分 2025-07-08 加入
Cryo-EM structures of GPR75 reveal an occluded orthosteric pocket challenging conventional drug discovery paradigms for an anti-obesity target
15天前
已完结
Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
23天前
已完结
Discovery of DFV890, a Potent Sulfonimidamide-Containing NLRP3 Inflammasome Inhibitor
24天前
已完结
Selective and Potent Molecular Glue Degraders for NIMA‐Related Kinase 7
27天前
已完结
Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome
27天前
已完结
Development of Degraders of Cyclin-Dependent Kinases 4 and 6 Based on Rational Drug Design
1个月前
已完结
Induced proximity pushes beyond protein degraders, as first RIPTAC moves into the clinic
2个月前
已完结
Antibody–Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer
2个月前
已完结
Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody–Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers
3个月前
已完结
Orphan G-protein coupled receptor 75 (GPR75), a unique and controversial potential therapeutic target
3个月前
已完结
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