Lv3
228 积分 2025-08-18 加入
Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers
1个月前
已完结
Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors
3个月前
已完结
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease
3个月前
已完结
Development of a highly potent and selective degrader of LRRK2
3个月前
已完结
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators
5个月前
已完结
Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors
6个月前
已完结
Development and therapeutic potential of adaptor-associated kinase 1 inhibitors in human multifaceted diseases
6个月前
已完结
Discovery, Structure–Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain
6个月前
已完结
Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design
6个月前
已完结
Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2
6个月前
已完结
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