Lv1
60 积分 2025-05-26 加入
Discovery of (S)-1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain
12天前
已完结
Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists
12天前
已完结
State-Dependent Inhibition of Nav1.8 Sodium Channels by VX-150 and VX-548
1个月前
已完结
Discovery of Selective Inhibitors for the Lysosomal Parkinson’s Disease Channel TMEM175
1个月前
已完结
Organocatalytic Decarboxylative Borylation of Cyclopropane N-Hydroxyphthalimide Esters
1个月前
已完结
COR388 (atuzaginstat): an investigational gingipain inhibitor for the treatment of Alzheimer disease
2个月前
已完结
Activatable Photoacoustic Probe for Imaging Infection: Gold Nanorod Dissociation In Vivo Reports Bacterial Protease Activity
2个月前
已完结
Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
2个月前
已完结
Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine
2个月前
已完结
2-Aminopyridines as Potent and Selective Nav1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model
3个月前
已完结
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