Lv31
300 积分 2024-01-03 加入
Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A
1小时前
已完结
Abstract 4268: The allosteric MAT2A inhibitor IDE397 uniquely exploits metabolic liabilities associated with MTAP deletion to perturb DNA replication and repair
5小时前
求助中
Structure-Based Discovery of a Series of Novel MAT2a Inhibitors
5小时前
已完结
Furo[2,3- f ]quinazolin-7(6 H )-one Derivatives as Potent, Selective, and Orally Bioavailable MAT2A Inhibitors for MTAP-Deficient Cancer Therapy
5小时前
已完结
Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads
5小时前
已完结
Design and Structural Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High In Vivo Potency and Oral Bioavailability
5小时前
已完结
Discovery of Novel Spirocyclic MAT2A Inhibitors Demonstrating High In Vivo Efficacy in MTAP-Null Xenograft Models
5小时前
已完结
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