Lv71
5015 积分 2021-02-02 加入
Akt Inhibitor Advancements: From Capivasertib Approval to Covalent-Allosteric Promises
6天前
已完结
Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase
8天前
已完结
Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases
9天前
已完结
Abstract 5788: Preclinical evaluation of HZB0071, a small molecule inhibitor of AKT
9天前
已关闭
Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys
24天前
已完结
Discovery of a Novel p38α-MK2 Complex Inhibitor as a Potential Choice for Autoimmune Diseases
1个月前
已完结
Discovery of small molecule degraders for modulating cell cycle
2个月前
已完结
Design, synthesis and antitumor activity of a novel FGFR2-selective degrader to overcome resistance of the FGFR2V564F gatekeeper mutation based on a pan-FGFR inhibitor
2个月前
已完结
Synthesis and identification of a selective FGFR2 degrader with potent antiproliferative effects in gastric cancer
2个月前
已完结
Development of selective FGFR1 degraders using a Rapid synthesis of proteolysis targeting Chimera (Rapid-TAC) platform
2个月前
已完结
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