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32 积分 2023-09-13 加入
Rewiring Oncogenic Transcriptional Complexes with Domain-ALTeration Chimeras (DALTACs) in Prostate Cancer
11小时前
已完结
Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling
1个月前
已完结
Hit to lead optimization of the 4-trifluoromethylquinoline derivatives as novel SGK1 inhibitors with potent anti-prostate cancer activity
1个月前
已完结
Overcoming CK1α liability in the discovery of a series of isoIndolinone Glutarimides as selective IKZF2 molecular glue degraders
1个月前
已完结
Brain Permeable SGK1 Inhibitors: A Promising Therapeutic Strategy for Neurodegenerative Diseases
1个月前
已完结
Bridged PROTAC, DNA-based PROTAC and hydrophobic tag technologies for targeted protein degradation
1个月前
已完结
Discovery of novel Keap1-targeting hydrophobic tag (HyT) tethering degraders with potent Nrf2 activation activity
1个月前
已完结
Hydrophobic Tag Degraders Overcome Endocrine‐Resistant Breast Cancer by Recruiting HSP27‐Mediated E3 Ligase Complex for ERα Proteasomal Degradation
1个月前
已完结
Biotransformation, spectroscopic investigation, crystal structure and electrostatic properties of 3,7α-dihydroxyestra-1,3,5(10)-trien-17-one monohydrate studied using transferred electron-density parameters
1个月前
已关闭
537MO First-in-human study of JNJ-64619178, a protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced cancers
1个月前
已完结
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