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38 积分 2023-09-13 加入
Expanding the targeted protein degradation approach with small molecule chimeras directed to the 26S proteasome
8天前
已完结
BCR::ABL1 Proteolysis-targeting chimeras (PROTACs): The new frontier in the treatment of Ph+ leukemias?
10天前
已完结
The recent advance of PROTACs targeting BCR-ABL for the treatment of chronic myeloid leukemia
10天前
已完结
Preclinical activity of CPI-0610, a novel small-molecule bromodomain and extra-terminal protein inhibitor in the therapy of multiple myeloma
25天前
已完结
Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery
25天前
已完结
Design, synthesis and biological evaluation of thioether-containing lenalidomide and pomalidomide derivatives with anti-multiple myeloma activity
25天前
已完结
Design, synthesis and biological evaluation of novel quinazolinone derivatives as CRBN E3 ligase modulators
25天前
已完结
Monoselective Histone Deacetylase 6 PROTAC Degrader Shows In Vivo Tractability
29天前
已完结
Modular PROTAC/IMiD Bifunctional Molecule Design for the Degradation of Synergistic Targets in the Treatment of Lymphoma
29天前
已完结
Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs
29天前
已完结
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