Lv34
388 积分 2023-08-04 加入
Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization
2天前
已完结
Targeted Degradation of Prolyl Hydroxylase Domain Enzyme 1 (PHD1) as a Novel Therapeutic Strategy for Acetaminophen-Induced Acute Liver Injury
2天前
已完结
An integrated machine learning and computational framework with experimental validation for the identification of novel CXCR4 inhibitors
9天前
已完结
Novobiocin defines an Asn28 allosteric pocket that governs SARS-CoV-2 main protease activity
9天前
已完结
Discovery of Preclinical Candidate CG-0988, a Novel Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease Inhibitor Bearing Spirooxindole
9天前
已完结
Rational molecular hybridization of indole–vinyl-substituted 4,5-diphenyloxazolium derivatives enables dual membrane and intracellular targeting for broad-spectrum antibacterial activity
9天前
已完结
Design, synthesis and biological evaluation of selective inhibitors against the L858R/T790 M/C797S mutant EGFR kinase based on the scaffold of brigatinib
9天前
已完结
Discovery and characterization of YSA64, a RBM39 degrader with in vivo efficacy and potent cellular activity in pediatric Ewing sarcoma A673
9天前
已完结
In silico studies, synthesis, and biological evaluation of novel imidazopyridine-based CYP4Z1 inhibitors targeting breast cancer stem cells
9天前
已完结
Design, synthesis, and evaluation of indole-pyridine chalcone derivatives as novel HK2 inhibitors to modulate macrophage glycolysis and inflammation for IBD treatment
9天前
已完结
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