Lv3
372 积分 2023-08-04 加入
An integrated machine learning and computational framework with experimental validation for the identification of novel CXCR4 inhibitors
4天前
已完结
Novobiocin defines an Asn28 allosteric pocket that governs SARS-CoV-2 main protease activity
4天前
已完结
Discovery of Preclinical Candidate CG-0988, a Novel Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease Inhibitor Bearing Spirooxindole
4天前
已完结
Rational molecular hybridization of indole–vinyl-substituted 4,5-diphenyloxazolium derivatives enables dual membrane and intracellular targeting for broad-spectrum antibacterial activity
4天前
已完结
Design, synthesis and biological evaluation of selective inhibitors against the L858R/T790 M/C797S mutant EGFR kinase based on the scaffold of brigatinib
4天前
已完结
Discovery and characterization of YSA64, a RBM39 degrader with in vivo efficacy and potent cellular activity in pediatric Ewing sarcoma A673
4天前
已完结
In silico studies, synthesis, and biological evaluation of novel imidazopyridine-based CYP4Z1 inhibitors targeting breast cancer stem cells
4天前
已完结
Design, synthesis, and evaluation of indole-pyridine chalcone derivatives as novel HK2 inhibitors to modulate macrophage glycolysis and inflammation for IBD treatment
4天前
已完结
Design, synthesis and structure-activity relationship study of novel indole-pyrrole scaffold compounds targeting Nur77 in colorectal tumor cells
4天前
已完结
Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns
11天前
已完结
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