Lv5
1080 积分 2024-03-27 加入
Induced proximity at the cell surface
1天前
待确认
Design of Potent and Selective BCL6 Transcriptional Chemical Inducers of Proximity through Linker Optimization
2天前
已完结
"Rapid Identification of a Potent, Selective, and Orally Active p300/CBP Bromodomain Inhibitor Bearing an Imidazo[1,2-a]pyridine Scaffold via a Highly Efficient Four-Step Synthesis
11天前
已完结
RIMTAC: A Novel Degrader Design Platform by Indirect VHL-Recruitment via RIPK1
22天前
已完结
Discovery of Highly Potent PROTAC Degrader of p300/CBP Proteins for the Treatment of Enzalutamide-Resistant Prostate Cancer
23天前
已完结
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy
28天前
已完结
Discovery of Novel CBP/p300 and BRD4 Dual-Target PROTACs with Potent Antitumor Activity in Prostate Cancer
29天前
已完结
Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs
1个月前
已完结
Generating Surprisingly Powerful Pharmacology from Chemically Induced Protein Interactions
1个月前
已完结
Proteomics-Driven Strategies for Proximity-Inducing Drug Discovery
1个月前
已完结
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