Lv5
1410 积分 2024-05-19 加入
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease
1天前
待确认
Rational Design, Synthesis, and Biological Evaluation of Potent, Highly Selective 1,2,4-Oxadiazole-Based S1PR1 Agonists for UC Treatment
6天前
已完结
Discovery and Optimization of 4-Aminopteridin-7(8 H )-one Derivatives as Potent and Selective mTOR Inhibitors with Favorable Pharmacodynamic and Safety Characteristics
8天前
已完结
Discovery of FLC-8 as the First Covalent FLT3 Inhibitor Targeting Cys807 for FLT3 Mutant Acute Myeloid Leukemia
14天前
已完结
Structure-Based Discovery of Imidazo[4,5- c ]pyridine SARM1 Modulators Showing Paradoxical Activation
14天前
已完结
A Nonequilibrium Simulation Framework for Reproducing Protein Aggregation in All-Atom Molecular Dynamics Simulations
15天前
已完结
Coordination of Anle138b to Silver Results in Selective Reduction of a C‐Terminal Truncated α‐Synuclein Protein and Increased Aggregate Size
21天前
已完结
β-Synuclein Intermediates α-Synuclein Neurotoxicity in Parkinson’s Disease
26天前
已完结
Organocatalyst-Controlled Stereoselective Head-to-Tail Macrocyclizations
1个月前
已完结
Conformational Ensemble Dynamics of Intrinsically Disordered Full-Length α- and β-Synuclein Monomers
1个月前
已完结
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