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50 积分 2025-02-05 加入
Discovery of a Novel CRBN-Recruiting cGAS PROTAC Degrader for the Treatment of Ulcerative Colitis
12天前
已完结
Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair
1个月前
已完结
Modulating TRADD to restore cellular homeostasis and inhibit apoptosis
1个月前
已完结
Addition of navitoclax to ongoing ruxolitinib treatment in patients with myelofibrosis (REFINE): a post-hoc analysis of molecular biomarkers in a phase 2 study
1个月前
已完结
Why Some Targets Benefit from beyond Rule of Five Drugs
2个月前
已完结
Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition
2个月前
已完结
Sorafenib and SIAIS361034, a novel PROTAC degrader of BCL-xL, display synergistic antitumor effects on hepatocellular carcinoma with minimal hepatotoxicity
3个月前
已完结
TJ0113 attenuates fibrosis in metabolic dysfunction-associated steatohepatitis by inducing mitophagy
3个月前
已完结
Celastrol Targets Hsc70‐Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis
3个月前
已完结
A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice
3个月前
已完结
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