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Synergistic and Antagonistic Antiproliferative Effects of Ribociclib (Lee011) and Irinotecan (SN38) on Colorectal Cancer Cells
16小时前
已完结
Covalent inhibitors of the RAS binding domain of PI3Ka impair tumor growth driven by RAS and HER2
7天前
已完结
Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders
17天前
已完结
CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers
17天前
已完结
Covalent inhibitors of K-Ras G12S, G12R, and G12D
27天前
已完结
Lysine-Targeted Covalent Strategy Leading to the Discovery of Novel Potent PROTAC-Based PI3Kδ Degraders
1个月前
已完结
Design, synthesis and activity study of a novel PI3K degradation by hijacking VHL E3 ubiquitin ligase
1个月前
已完结
PI3K PROTAC overcomes the lapatinib resistance in PIK3CA-mutant HER2 positive breast cancer
1个月前
已完结
Journey of Von Hippel-Lindau (VHL) E3 ligase in PROTACs design: From VHL ligands to VHL-based degraders
1个月前
已完结
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα
1个月前
已完结
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