Lv2
160 积分 2025-03-18 加入
A Type II CDK6 Degrader Enables Cellular Targeting beyond the Limits of Type II Inhibition
2天前
已完结
Targeting both wild-type EGFR and its drug-resistant mutants with erlotinib-aptamer conjugates
28天前
已完结
LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity
1个月前
已完结
Structure-Aided Design, Synthesis, and Biological Evaluation of Potent and Selective Non-Nucleoside Inhibitors Targeting Protein Arginine Methyltransferase 5
1个月前
已完结
Crystal structure of the human PRMT5:MEP50 complex
1个月前
已完结
Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor
1个月前
已完结
Monosaccharide-Linked Inhibitors of O6-Methylguanine-DNA Methyltransferase (MGMT): Synthesis, Molecular Modeling, and Structure−Activity Relationships
3个月前
已完结
Resistance-Modifying Agents. 8. Inhibition of O6-Alkylguanine-DNA Alkyltransferase by O6-Alkenyl-, O6-Cycloalkenyl-, and O6-(2-Oxoalkyl)guanines and Potentiation of Temozolomide Cytotoxicity in Vitro by O6-(1-Cyclopentenylmethyl)guanine
3个月前
已完结
8-Substituted O6-Benzylguanine, Substituted 6(4)-(Benzyloxy)pyrimidine, and Related Derivatives as Inactivators of Human O6-Alkylguanine-DNA Alkyltransferase
3个月前
已完结
Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase
3个月前
已完结
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