Lv33
250 积分 2025-03-18 加入
MGMT-inhibitor in combination with TGF-βRI inhibitor or CDK 4/6 inhibitor increases temozolomide sensitivity in temozolomide-resistant glioblastoma cells
7分钟前
待确认
Rad51 and BRCA2 - New Molecular Targets for Sensitizing Glioma Cells to Alkylating Anticancer Drugs
11天前
已完结
Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide
11天前
已完结
Discovery of novel 20S proteasome subunit β5 PROTAC degraders as potential therapeutics for pharyngeal carcinoma and Bortezomib-resistant multiple myeloma
22天前
已完结
PEAKS activation by PROTAC EPIC-0726 potentiates temozolomide in glioblastoma via K63/K48 ubiquitination-dependent ERK/AKT suppression and p21 stabilization
22天前
已完结
Discovery of Tricyclic Oxazinoquinolinone-Based BCL6 PROTAC Degraders with Potent Activity Against Diffuse Large B-Cell Lymphoma
23天前
已完结
Discovery of a Potent NAMPT-Targeting PROTAC for the Suppression of Triple-Negative Breast Cancer via Macrophage Reprogramming
27天前
已完结
Structure-Aided Design, Synthesis, and Biological Evaluation of Potent and Selective Non-Nucleoside Inhibitors Targeting Protein Arginine Methyltransferase 5
2个月前
已完结
Rational Design of Dual Degraders by Incorporating Molecular Glue Structural Features into PROTAC Degraders
2个月前
已完结
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
2个月前
已完结
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