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60 积分 2024-09-24 加入
Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human Kinome
16小时前
待确认
Aquaporin-9 Protein Is the Primary Route of Hepatocyte Glycerol Uptake for Glycerol Gluconeogenesis in Mice
6天前
已关闭
DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders
10天前
已完结
Discovery of Atirmociclib (PF-07220060): A Potent and Selective CDK4 Inhibitor
10天前
已完结
Discovery of Novel Trisubstituted Pyridine Derivatives as EED–H3K27me3 Inhibitors for the Treatment of Multiple Sclerosis
14天前
已完结
Structural and Kinetic Basis for the Rational Design of Next-Generation β-Lactamase Inhibitors
16天前
已关闭
Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12C
16天前
已完结
C-Arg9-APCR3-VHL promotes β-catenin degradation via the VHL-mediated ubiquitin–proteasome system in APC-mutant colorectal cancer
17天前
已完结
Recruitment of FBXO22 for Targeted Degradation of NSD2
20天前
已完结
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22
20天前
已关闭
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