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38 积分 2024-11-26 加入
Phenotypic Screening for Targeted Protein Degradation: Strategies, Challenges, and Emerging Opportunities
1个月前
已完结
Two decades of PARP inhibitor synthetic lethality in cancer
1个月前
已完结
A Scalable, Direct‐to‐Biology Platform for Accelerated Discovery of Cereblon‐Based Molecular Glue Degraders
1个月前
已完结
Unhooking the Hook: Optimization of the Aurora A Targeting PROTAC JB170 to CCT400028 , an In Vitro Degrader Chemical Probe
1个月前
已完结
Optimization of novel quinazolinone derivatives as CRBN E3 ligase modulators for enhanced degradative activity and metabolic stability
1个月前
已完结
A sinomenine derivative protects life-threatening inflammatory injuries via covalently binding to a novel allosteric inhibition site of IRF3
1个月前
已完结
A robust protocol for Pd(ii)-catalyzed C-3 arylation of (1H) indazoles and pyrazoles: total synthesis of nigellidine hydrobromide
1个月前
已完结
Development of Dual-Receptor Lysosome-Targeting Chimeras for Protein Degradation
2个月前
已完结
Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators
3个月前
已完结
Discovery of a Novel CRBN-Recruiting cGAS PROTAC Degrader for the Treatment of Ulcerative Colitis
3个月前
已完结
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