Lv11
30 积分 2020-12-06 加入
Beyond Bioisosteres: Impact of Replacing a Benzene Ring with sp3-Rich Three-Dimensional Saturated Bridged Bicyclic Match Pairs on Biotransformation, Metabolic Stability, and Other ADME Profiles
3小时前
待确认
Discovery of Potent and Selective BCL6 Ligand-Directed Degrader (LDD), BCL6-760
3小时前
已完结
Discovery of Fluoroalkenes as Dual Inhibitors of Diacylglycerol Kinases Alpha and Zeta (DGKα/ζ)
3小时前
已完结
Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127
16天前
已完结
Discovery of BRD9 Molecular Glue Degraders That Spare Cardiomyocytes
17天前
已完结
[1,2,4]Triazolo[1,5-a]pyrimidine Phosphodiesterase 2A Inhibitors: Structure and Free-Energy Perturbation-Guided Exploration
1个月前
已完结
Discovery of Selective and Orally Bioavailable Heterobifunctional Degraders of Cyclin-Dependent Kinase 2
1个月前
已完结
Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader
1个月前
已完结
Testing the time-scale dependence of delayed interactions: A heat wave during the egg stage shapes how a pesticide interacts with a successive heat wave in the larval stage
2个月前
已完结
Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells
2个月前
已完结
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